In order to improve the large space, reduce the amount of large space columns, in this paper, a restaurant is built on the cruise ship project section large space structure analysis, compare the specifications, mechanical calculation and beam finite element calculation, the plate girder structure finite element calculation and analysis for pillar of weight, the size of the structure, headroom, the influence of structure deformation, The sensitivity of large space column design is analyzed, which provides reference for the design of large space structure column of cruise ship.